Henry Houlden Selected Research

adenomatous polyposis coli protein 2

10/2019

Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay.

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Henry Houlden Research Topics

Disease

26	Parkinson Disease (Parkinson's Disease) 05/2022 - 07/2009
19	Ataxia (Dyssynergia) 01/2022 - 05/2010
18	Parkinsonian Disorders (Parkinsonism) 01/2022 - 01/2009
18	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2021 - 12/2010
15	Dystonia (Limb Dystonia) 11/2022 - 01/2009
12	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 09/2012
10	Neurodevelopmental Disorders 08/2022 - 01/2019
10	Seizures (Absence Seizure) 01/2022 - 11/2014
10	Multiple System Atrophy 01/2021 - 01/2003
9	Intellectual Disability (Idiocy) 04/2022 - 11/2014
9	Brain Diseases (Brain Disorder) 01/2022 - 01/2016
9	Nervous System Diseases (Neurological Disorders) 01/2022 - 01/2016
9	Hereditary Spastic Paraplegia 01/2022 - 03/2011
9	Atrophy 01/2022 - 01/2009
8	Dementia (Dementias) 01/2021 - 08/2011
6	Epilepsy (Aura) 01/2022 - 10/2012
6	Muscular Diseases (Myopathy) 01/2022 - 01/2018
6	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 06/2003
6	Cognitive Dysfunction 01/2021 - 09/2010
6	Frontotemporal Dementia (Semantic Dementia) 08/2020 - 09/2012
6	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 04/2014
6	Cerebellar Ataxia (Dysmetria) 01/2018 - 05/2010
6	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2018 - 12/2007
6	Hereditary Sensory and Autonomic Neuropathies (HSAN) 12/2017 - 08/2003
5	Movement Disorders (Movement Disorder) 01/2022 - 07/2010
5	Ischemic Stroke 03/2021 - 10/2015
5	Atrial Fibrillation 03/2021 - 10/2015
5	Leukoencephalopathies 01/2021 - 12/2016
5	Inborn Genetic Diseases (Disease, Hereditary) 03/2020 - 09/2018
5	Brown-Vialetto-Van Laere syndrome 11/2017 - 09/2012
5	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/2017 - 11/2004
4	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 07/2022 - 01/2019
4	Cerebral Small Vessel Diseases 07/2022 - 11/2014
4	Disease Progression 05/2022 - 03/2012
4	Synucleinopathies 12/2019 - 02/2015
3	Cerebral Hemorrhage 01/2022 - 10/2015
3	Microcephaly 01/2022 - 12/2019
3	Muscle Hypotonia (Hypotonia) 10/2021 - 01/2019
3	Huntington Disease (Huntington's Disease) 08/2021 - 06/2016
3	Polyneuropathies (Polyneuropathy) 01/2021 - 01/2019
3	Intracranial Aneurysm (Cerebral Aneurysm) 01/2021 - 06/2018
3	Stroke (Strokes) 10/2020 - 10/2015
3	Inflammation (Inflammations) 03/2020 - 01/2019
3	Optic Atrophy 01/2020 - 11/2017
3	Pain (Aches) 08/2019 - 01/2017
3	Neoplasms (Cancer) 01/2019 - 04/2017
3	Muscle Weakness 01/2018 - 04/2014
3	Multiple Sclerosis 01/2018 - 01/2016
3	Neurodegeneration with brain iron accumulation (NBIA) 03/2016 - 04/2012
3	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 02/2015 - 12/2003
3	Gaucher Disease (Gaucher's Disease) 02/2013 - 07/2009
2	Infantile Epileptic-Dyskinetic Encephalopathy 08/2022 - 01/2021
2	Myoclonus (Nocturnal Myoclonus) 01/2022 - 07/2012
2	Tauopathies 01/2022 - 09/2012
2	Dyskinesias (Dyskinesia) 01/2022 - 07/2010
2	Rare Diseases (Rare Disease) 08/2021 - 09/2014
2	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 08/2021 - 10/2017
2	Sensorineural Hearing Loss 06/2021 - 11/2014
2	Amyloid Plaque 01/2021 - 06/2003
2	Migraine Disorders (Migraine) 01/2021 - 09/2014
2	Autism Spectrum Disorder 01/2021 - 12/2017
2	Paraplegia (Spastic Paraplegia) 01/2021 - 12/2017

Drug/Important Bio-Agent (IBA)

49	Proteins (Proteins, Gene)FDA Link 03/2022 - 05/2010
15	SynucleinsIBA 01/2021 - 08/2011
13	IronIBA 01/2022 - 01/2009
10	Levodopa (L Dopa)FDA LinkGeneric 01/2022 - 01/2009
9	Biomarkers (Surrogate Marker)IBA 12/2022 - 01/2018
9	alpha-SynucleinIBA 01/2018 - 01/2003
8	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 07/2014
7	Leucine (L-Leucine)FDA Link 01/2022 - 09/2012
7	Phosphotransferases (Kinase)IBA 01/2021 - 12/2007
6	Pharmaceutical PreparationsIBA 01/2022 - 09/2017
6	Riboflavin (Vitamin B2)FDA LinkGeneric 03/2018 - 09/2012
5	AnticoagulantsIBA 03/2021 - 10/2015
5	Biological ProductsIBA 03/2021 - 08/2011
5	Amyloid (Amyloid Fibrils)IBA 01/2021 - 06/2003
5	Mitochondrial DNA (mtDNA)IBA 06/2017 - 09/2012
5	Glucosylceramidase (Glucocerebrosidase)IBA 02/2013 - 07/2009
4	Transcription Factors (Transcription Factor)IBA 11/2022 - 12/2011
4	Apolipoproteins E (ApoE)IBA 07/2022 - 04/2015
4	polyglutamineIBA 01/2022 - 01/2016
4	CalciumIBA 01/2022 - 07/2014
4	EnzymesIBA 01/2022 - 02/2013
3	ADP-ribosylarginine hydrolaseIBA 12/2021 - 01/2018
3	Carrier Proteins (Binding Protein)IBA 12/2021 - 12/2003
3	RNA (Ribonucleic Acid)IBA 01/2021 - 04/2014
3	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 01/2018
3	AMPA Receptors (AMPA Receptor)IBA 12/2019 - 01/2016
3	Adenosine Triphosphate (ATP)IBA 12/2017 - 04/2013
2	ApolipoproteinsIBA 07/2022 - 04/2015
2	Lysine (L-Lysine)FDA Link 04/2022 - 02/2017
2	Dihydroxyphenylalanine (Dopa)IBA 01/2022 - 10/2020
2	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 01/2022 - 04/2017
2	CationsIBA 01/2022 - 06/2010
2	tributyl phosphate (TBP)IBA 01/2022 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2022 - 01/2020
2	Replication Protein C (Replication Factor C)IBA 03/2021 - 01/2019
2	VitaminsIBA 01/2021 - 05/2017
2	Codon (Codons)IBA 01/2021 - 01/2017

Therapy/Procedure

8	Therapeutics 08/2021 - 10/2015